Experiences
Computational model predicting ligand-specific protein binding-sites
AIgenDrug Co. Ltd., Seoul
Interpretation of Ensemble-based kinase-ligand prediction method
Incorporating a ’chemist’ perspective inside algorithms
’Interpretable’ drug-target interaction prediction tools
Embedding space of protein structures
Bio & Health Informatics Lab, SNU
Prebiotic peptide ligation & synthesis of homocystamine
Organic chemists’ approach on biochemical molecules
Pre-biotic peptide ligation in water: without protein & RNA
Synthesis of homocystamine via ring-opening
Laboratory of Protometabolism & Prebiotic Chemistry, UCL
Synthesis of Perpendicular Directed Molecular Building Block
Design & synthesis of organic perpendicular building-block
Chracterization via Xtal and fluorescence assay
Expansion via Pd-catalyzed coupling
Stimuli-Responsive Chemical Systems Lab, SNU
Characterization and Engineering of Novel Omega-Ester Containing Peptides
DNA cloning, protein expression, and activity assays
Extensive MATLDI-TOF for peptide topology determination
Fluorescence assay for protein activity analysis
Laboratory of Proteolytic Systems, SNU
Publication
Genome Mining Reveals High Topological Diversity of w-Ester-Containing Peptides and Divergent Evolution of ATP-Grasp Macrocyclases
Hyunbin Lee, Mingyu Choi, Jung-un Park, Heejin Roh, Seokhee Kim
J. Am. Chem. Soc., 2020 [Link(ACS)]
Conference Presentations
Developing a Geometrically Perpendicular Organic “Turn” Motif
Jun.2019 | Seoul, Korea
Undergraduate Research Conference, SNU Chemistry
Outstanding Research Presentation : 1st Prize
Poster will be uploaded after publication.
Cross-Reactivity of Microviridin-like RiPPs and Generation of Multi-Cyclic Peptides [pdf]
Jun.2018 | Seoul, Korea
Undergraduate Research Conference, SNU Chemistry
Outstanding Research Presentation : 2nd Prize
Discovery and Characterization of Novel Microviridin-like RiPPs [pdf]
Dec.2017 | Seoul, Korea
Undergraduate Research Conference, SNU Chemistry
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Society Participation
The 2021 Annual Conference of Korean Society for Bioinformatics (BIOINFO 2021)
Oct.2021 | Seoul, Korea
2019 KCS Inorganic Chemistry Division Summer Symposium(INORG2019)
Jun.2019 | Busan, Korea
Tutorial Session Participant: Electrochemisry lecture & Gaussion tutorial session.